Here are a few KB articles to review before upgrading to version 6

Upgrading to Simplify Suite v6
Upgrading to Simplify Suite v6

Upgrading to ScrewDrivers v6
Upgrading to ScrewDrivers v6

Remote Desktop Protocol Changes for Windows Server 2012
Remote Desktop Protocol Changes for Windows Server 2012

Windows 7 Dynamic Virtual Channel support
Windows 7 Dynamic Virtual Channel support

ScrewDrivers Client Monitoring
ScrewDrivers Client Monitoring

Inform End Users of ScrewDrivers Client versions that are to be deprecated
Inform End Users of ScrewDrivers Client versions that are to be deprecated

Complete Product version history
Version History